HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Iodopyridine → 3-Nitro-2-[4-(3-pyridin-2-ylprop-2-ynylidene)piperidin-1-yl]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Iodopyridine | HCID 221126 | — |
| Reactant | Diethyl (3-trimethylsilylprop-2-ynyl)phosphonate | HCID 10933869 | — |
| Reactant | 3-Nitro-2-(4-prop-2-ynylidenepiperidin-1-yl)pyridine | HCID 86627335 | — |
| Product | 3-Nitro-2-[4-(3-pyridin-2-ylprop-2-ynylidene)piperidin-1-yl]pyridine | HCID 86627336 | — |
Reaction Steps
The title compound was obtained as described for the Compound of Example 1, reacting Compound 1c with 2-iodopyridine instead of 2-bromo-6-methylpyridine. The crude was purified by flash chromatography (EtOAc—Petroleum Ether 1:1) affording the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08518916B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-fb51c5bec6e1408e9d81e8adc0d7050e |
| Source note | uspto-grants-2013_08 |