2-Chloro-3-nitropyridine → HCID 68723887, compound

HRID 1895961Notes

Reaction equation

HRID 1895961 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH2:8][C:9]#[C:10][CH:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)[N:3]=1.Cl[C:18]1[C:23]([N+:24]([O-:26])=[O:25])=[CH:22][CH:21]=[CH:20][N:19]=1>>[CH3:1][C:2]1[N:3]=[C:4]([C:8]#[C:9][CH2:10][CH:11]2[CH2:12][CH2:13][N:14]([C:18]3[C:23]([N+:24]([O-:26])=[O:25])=[CH:22][CH:21]=[CH:20][N:19]=3)[CH2:15][CH2:16]2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 796132-Chloro-3-nitropyridineHCID 68976689HCID 68976689, compound

Product 1

HCID 68723887HCID 68723887, compoundYield 54.1%

Procedure

A well homogenised mixture of Compound 31a (24 mg, 0.11 mmol) and 2-chloro-3-nitropyridine (19.5 mg, 0.12 mmol) was stirred at 120° C. for 40 min. The reaction crude was purified by flash chromatography (EtOAc—Petroleum Ether 3:7) affording the title product (20 mg).

Workup

  1. stirringwas stirred at 120° C. for 40 min
  2. customThe reaction crude
  3. customwas purified by flash chromatography (EtOAc—Petroleum Ether 3:7)

Sources & evidence

ORD record
ord-983693ba9e0141c4a06cb15e62ade052
Source dataset
uspto-grants-2013_08
Patent number
US08518916B2

Reaction notes

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