HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Bromo-4-cyanopyridine → Tert-butyl 4-[3-(6-cyanopyridin-3-yl)prop-2-ynylidene]piperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Bromo-4-cyanopyridine | HCID 11074051 | — |
| Reactant | Tert-butyl 4-[3-(5-cyanopyridin-3-yl)prop-2-ynylidene]piperidine-1-carboxylate | HCID 25183829 | — |
| Product | Tert-butyl 4-[3-(6-cyanopyridin-3-yl)prop-2-ynylidene]piperidine-1-carboxylate | HCID 87550158 | — |
Reaction Steps
The title compound was prepared following the procedure described for the compound of Example 45, but substituting 5-bromo-2-pyridincarbonitrile for 5-bromoisonicotinonitrile. Purification by flash chromatography (EtOAc—Petroleum Ether gradient from 5:95 to 40:60) afforded the title product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08518916B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-d53905849466442ca9aed706d6195d72 |
| Source note | uspto-grants-2013_08 |