HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenylacetylene → tert-Butyl 4-(1-Fluoro-3-phenylprop-2-ynylidene)piperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenylacetylene | HCID 10821 | — |
| Reactant | Tert-butyl 4-[3-(5-cyanopyridin-3-yl)prop-2-ynylidene]piperidine-1-carboxylate | HCID 25183829 | — |
| Reactant | Tert-butyl 4-[bromo(fluoro)methylidene]piperidine-1-carboxylate | HCID 68795703 | — |
| Reactant | tert-Butyl 4-(prop-2-yn-1-ylidene)piperidine-1-carboxylate | HCID 86661548 | — |
| Product | tert-Butyl 4-(1-Fluoro-3-phenylprop-2-ynylidene)piperidine-1-carboxylate | HCID 86627338 | — |
Reaction Steps
The title product was prepared following the procedure reported for the Compound of Example 45 but using phenylacetylene instead of instead of Compound 2b and Compound 66a instead of 5-bromonicotinonitrile. The residue coming from the usual work-up procedure was purified by flash chromatography (EtOAc—Petroleum Ether gradient from 5:95 to 10:90).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08518916B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-251b94293d13405c9c9456a5730860d3 |
| Source note | uspto-grants-2013_08 |