2-Chloro-6-methyl-3-nitropyridine → HCID 68724968, compound

HRID 1895998Notes

Reaction equation

HRID 1895998 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH2:8][C:9]#[C:10][CH:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)[N:3]=1.Cl[C:18]1[C:23]([N+:24]([O-:26])=[O:25])=[CH:22][CH:21]=[C:20]([CH3:27])[N:19]=1>>[CH3:27][C:20]1[N:19]=[C:18]([N:14]2[CH2:13][CH2:12][CH:11]([CH2:10][C:9]#[C:8][C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([CH3:1])[N:3]=3)[CH2:16][CH2:15]2)[C:23]([N+:24]([O-:26])=[O:25])=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 12682302-Chloro-6-methyl-3-nitropyridineHCID 68976689HCID 68976689, compound

Product 1

HCID 68724968HCID 68724968, compound

Procedure

The title compound was prepared following the procedure described for the Compound of Example 31, using 2-chloro-3-nitro-6-picoline instead of 2-bromo-3-nitropyridine. The crude was purified by automated flash liquid chromatography (Horizon™-Biotage) eluting with Petroleum Ether/EtOAc 7:3, affording the title product as a yellow oil.

Workup

  1. customThe title compound was prepared
  2. customThe crude was purified by automated flash liquid chromatography (Horizon™-Biotage)
  3. washeluting with Petroleum Ether/EtOAc 7:3

Sources & evidence

ORD record
ord-251a297bc95c45a6912ddd98af5dd4ce
Source dataset
uspto-grants-2013_08
Patent number
US08518916B2

Reaction notes

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