Tert-butyl 4-[3-(3,5-difluorophenyl)prop-2-yn-1-yl]piperidine-1-carboxylate → 4-[3-(3,5-Difluorophenyl)prop-2-ynyl]piperidine

HRID 1895999Notes

Reaction equation

HRID 1895999 reaction equation
CC1C=CC=C(C#CC=C2CCNCC2)N=1.[F:17][C:18]1[CH:19]=[C:20]([C:25]#[C:26][CH2:27][CH:28]2[CH2:33][CH2:32][N:31](C(OC(C)(C)C)=O)[CH2:30][CH2:29]2)[CH:21]=[C:22]([F:24])[CH:23]=1>>[F:17][C:18]1[CH:19]=[C:20]([C:25]#[C:26][CH2:27][CH:28]2[CH2:29][CH2:30][NH:31][CH2:32][CH2:33]2)[CH:21]=[C:22]([F:24])[CH:23]=1

Participants

3

Reactant 2

HCID 68726123Tert-butyl 4-[3-(3,5-difluorophenyl)prop-2-yn-1-yl]piperidine-1-carboxylateHCID 875504022-Methyl-6-(3-piperidin-4-ylideneprop-1-ynyl)pyridine

Product 1

HCID 689794914-[3-(3,5-Difluorophenyl)prop-2-ynyl]piperidine

Procedure

The title compound was prepared following the procedure described for the Compound of Example 3, using the Compound of Example 247 instead of the Compound of Example 2. After the usual work-up procedure, the crude was used for the next step without further purification.

Workup

  1. customAfter the usual work-up procedure, the crude was used for the next step without further purification

Sources & evidence

ORD record
ord-76778855337f410894fdcfa7854d8862
Source dataset
uspto-grants-2013_08
Patent number
US08518916B2

Reaction notes

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