HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromobenzonitrile → 2-{4-[3-(3,5-Difluorophenyl)prop-2-yn-1-yl]piperidin-1-yl}benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromobenzonitrile | HCID 16272 | — |
| Reactant | 2-Methyl-6-[3-(1-phenylpiperidin-4-ylidene)prop-1-ynyl]pyridine | HCID 25183826 | — |
| Reactant | 4-[3-(3,5-Difluorophenyl)prop-2-ynyl]piperidine | HCID 68979491 | — |
| Product | 2-{4-[3-(3,5-Difluorophenyl)prop-2-yn-1-yl]piperidin-1-yl}benzonitrile | HCID 68723767 | — |
Reaction Steps
The title compound was prepared following the procedure described for the compound of Example 42, but using Compound 248a instead of the Compound of Example 3 and 2-bromobenzonitrile instead of bromobenzene. The crude was purified by preparative RP LC-MS chromatography, using MS-C18 XTerra column 30×50 mm eluting with ammonium bicarbonate 20 mM pH 8 buffer-acetonitrile gradient, affording the title product as a brown oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08518916B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-cd286be701e8456f9a839329b4d9077e |
| Source note | uspto-grants-2013_08 |