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HRID1896039

反应详情

EQUATION

反应方程式

HRID 1896039 的结构方程式

REACTANTS

反应物

4
结构：CC(=O)c1cccc(I)c1
HCID84449

Ethanone, 1-(3-iodophenyl)-

C8H7IO

结构：COc1c(F)cc(Br)cc1F
HCID2773287

4-Bromo-2,6-difluoroanisole

C7H5BrF2O

结构：C#CC=C1CCN(c2ncccc2[N+](=O)[O-])CC1
HCID86627335

未命名化合物

结构：COc1c(F)cc(C#CC=C2CCN(c3ncccc3[N+](=O)[O-])CC2)cc1F
HCID86627339

未命名化合物

PRODUCTS

生成物

1
结构：CC(=O)c1cccc(C#CC=C2CCN(c3nc(C)ccc3[N+](=O)[O-])CC2)c1
HCID87550106

未命名化合物

收率 84.3%

PROCEDURE

实验过程

The title compound was prepared in the same way as the Compound of Example 199 but substituting Compound 274c for Compound 1c and 1-(3-iodophenyl)ethanone for 4-bromo-2,6-difluoranisole. After the work-up, the residue was purified by automated flash liquid chromatography (SP1™-Biotage) eluting with PE-EtOAc gradient from 9:1 to 8:2 affording the title product. Yellow oil. Yield: 84.3%.

WORKUP

后处理

  1. customAfter the work-up, the residue was purified by automated flash liquid chromatography (SP1™-Biotage)
  2. washeluting with PE-EtOAc gradient from 9:1 to 8:2 affording the title product