HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanone, 1-(3-iodophenyl)- → 1-(3-{3-[1-(6-Methyl-3-nitropyridin-2-yl)piperidin-4-ylidene]prop-1-ynyl}phenyl)ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanone, 1-(3-iodophenyl)- | HCID 84449 | — |
| Reactant | 4-Bromo-2,6-difluoroanisole | HCID 2773287 | — |
| Reactant | 3-Nitro-2-(4-prop-2-ynylidenepiperidin-1-yl)pyridine | HCID 86627335 | — |
| Reactant | 2-(4-(3-(3,5-Difluoro-4-methoxyphenyl)prop-2-yn-1-ylidene)piperidin-1-yl)-3-nitropyridine | HCID 86627339 | — |
| Product | 1-(3-{3-[1-(6-Methyl-3-nitropyridin-2-yl)piperidin-4-ylidene]prop-1-ynyl}phenyl)ethanone | HCID 87550106 | 84.3% |
Reaction Steps
The title compound was prepared in the same way as the Compound of Example 199 but substituting Compound 274c for Compound 1c and 1-(3-iodophenyl)ethanone for 4-bromo-2,6-difluoranisole. After the work-up, the residue was purified by automated flash liquid chromatography (SP1™-Biotage) eluting with PE-EtOAc gradient from 9:1 to 8:2 affording the title product. Yellow oil. Yield: 84.3%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08518916B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-82fa4e8a1404414fb3fa4a21ce3d7f3a |
| Source note | uspto-grants-2013_08 |