Pyridinium chloride → HCID 10483384, compound

HRID 1896062Notes

Reaction equation

HRID 1896062 reaction equation
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[S:10][CH2:11][CH2:12][N:13]1[CH2:18][CH2:17][N:16]([CH2:19][C:20]([NH:22][C:23]2[C:24]([CH3:34])=[N:25][C:26]([CH3:33])=[CH:27][C:28]=2[C:29]([F:32])([F:31])[F:30])=[O:21])[CH2:15][CH2:14]1.[ClH:35].N1C=CC=CC=1>C(O)C>[ClH:35].[ClH:35].[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[S:10][CH2:11][CH2:12][N:13]1[CH2:14][CH2:15][N:16]([CH2:19][C:20]([NH:22][C:23]2[C:24]([CH3:34])=[N:25][C:26]([CH3:33])=[CH:27][C:28]=2[C:29]([F:32])([F:31])[F:30])=[O:21])[CH2:17][CH2:18]1

Participants

4

Reactant 2

HCID 10176127Pyridinium chlorideHCID 10483385HCID 10483385, compound

Product 1

HCID 10483384HCID 10483384, compoundYield 55%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-[4-[2-(benzothiazol-2-ylthio)ethyl]piperazin-1-yl]-N-[2,6-dimethyl-4-trifluoromethyl-3-pyridyl]acetamide (500 mg, 0.98 mmol) was dissolved in ethanol (10 mL), followed by the addition of pyridine hydrochloride (227 mg, 1.96 mmol). The reaction mixture was concentrated, and to the residue, ethanol (0.2 mL) and water (2 mL) were added. A precipitate was collected by filtration to obtain the title compound (295 mg, 55%) as a colorless crystalline powder.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. additionto the residue, ethanol (0.2 mL) and water (2 mL) were added
  3. filtrationA precipitate was collected by filtration

Sources & evidence

ORD record
ord-fb0aa8927646486db8252058c93e6463
Source dataset
uspto-grants-2013_08
Patent number
US08518936B2

Reaction notes

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