反应详情

温度

5 °C

Seven grams of 2-mercaptopyrazolo[1,5-a][1,3,5]triazin-4-ol (prepared according to the method described in Chemische Berichte, 1971, 104:3039-47) was dissolved in 5% aqueous NaOH (100 mL). The solution was cooled to 5° C. (ice bath) and 6 g. of methyl iodide was added dropwise. After 15-20 minutes, charcoal was added and the mixture was filtered then acidified with acetic acid. The precipitate (2-(methylthio)pyrazolo[1,5-a][1,3,5]triazin-4-ol was filtered, dried and isolated. Further recrystallization in AcOH gave 2-(methylthio)pyrazolo[1,5-a][1,3,5]triazin-4-ol. MS (ES+): 183.0 (M+1)+.

1. filtrationthe mixture was filtered
2. filtrationThe precipitate (2-(methylthio)pyrazolo[1,5-a][1,3,5]triazin-4-ol was filtered
3. customdried
4. customisolated
5. customFurther recrystallization in AcOH