反应详情

温度

50 °C

A mixture of carbonyldiimidazole (12.3 g, 76.1 mmol) in acetonitrile (123 mL) was warmed to 50° C. The 4-amino-1-(2-ethoxyethyl)-3-ethyl-1H-pyrazole-5-carboxamide prepared in step 3 (13.2 g, 58 mmol) was added to the mixture over a period of one hour and the temperature of the mixture was increased to 75° C. during the addition. The mixture was then cooled and stirred overnight. The mixture was cooled in an ice bath and filtered. The filter cake was rinsed with water and dried to provide 12.8 g of the title compound.

1. temperaturethe temperature of the mixture was increased to 75° C. during the addition
2. temperatureThe mixture was then cooled
3. temperatureThe mixture was cooled in an ice bath
4. filtrationfiltered
5. washThe filter cake was rinsed with water
6. customdried