Ammonia → Cyclohexaneacetamide

HRID 1896235ノート

反応式

HRID 1896235 の反応式
[NH3:1].[CH:2]1([CH2:8][C:9](Cl)=[O:10])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1>C(Cl)(Cl)Cl>[CH:2]1([CH2:8][C:9]([NH2:1])=[O:10])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1

参加物

4

反応物 2

HCID 222AmmoniaHCID 2757989Cyclohexylacetyl chloride

生成物 1

HCID 95078Cyclohexaneacetamide収率 87.8%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒2 回

実験手順

Aqueous ammonia was added to solution of 2-cyclohexylacetyl chloride (500 mg, 3.11 mmol) in CHCl3 (10 ml). After completion of reaction, the reaction mixture was diluted with CHCl3 (2×30 ml). The organic layer was washed with saturated sodium bicarbonate solution, brine and dried over anhydrous sodium sulfate. The organic layer was concentrated under vacuum, crude compound was washed with hexane (2×8 ml) and dried to afford 400 mg (87.8%) of 2-cyclohexylacetamide.

後処理

  1. customAfter completion of reaction
  2. washThe organic layer was washed with saturated sodium bicarbonate solution, brine
  3. dry with materialdried over anhydrous sodium sulfate
  4. concentrationThe organic layer was concentrated under vacuum, crude compound
  5. washwas washed with hexane (2×8 ml)
  6. customdried

出典と根拠

ORDレコード
ord-c93a3dd1950a4c7bb61a282461bd2694
出典データセット
uspto-grants-2013_08
特許番号
US08518948B2

反応ノート

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