Ammonia → HCID 22716506, compound

HRID 1896252Notes

Reaction equation

HRID 1896252 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]([CH3:11])[C:7](OC)=[O:8].[NH3:12]>>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]([CH3:11])[C:7]([NH2:12])=[O:8]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 12819459HCID 12819459, compound

Product 1

HCID 22716506HCID 22716506, compoundYield 71.3%

Conditions

Temperature
70 °C

Procedure

Methanolic ammonia (10 ml) was added to methyl 2-(thiophen-2-yl)propanoate (200 mg, 1.17 mmol) in sealed tube, the reaction mixture was heated to 70° C. for 18 h. The volatiles were evaporated and the residue was washed with n-pentane to afford 130 mg (71.3%) of 2-(thiophen-2-yl)propanamide as brown color solid.

Workup

  1. customThe volatiles were evaporated
  2. washthe residue was washed with n-pentane

Sources & evidence

ORD record
ord-5943e8804078495ba67f0d9e9e5e800e
Source dataset
uspto-grants-2013_08
Patent number
US08518948B2

Reaction notes

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