Ammonia → HCID 50995660, compound

HRID 1896261Notes

Reaction equation

HRID 1896261 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]([CH3:14])[CH2:8][C:9](OCC)=[O:10])[CH:2]=1.[NH3:15]>>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]([CH3:14])[CH2:8][C:9]([NH2:15])=[O:10])[CH:2]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 12727116HCID 12727116, compound

Product 1

HCID 50995660HCID 50995660, compoundYield 47%

Procedure

A solution of ethyl 3-(pyridin-3-yl)butanoate (0.50 g, 2.59 mmol) in methanolic ammonia (10 ml) was heated to 100° C. in a pressure bomb overnight. The solvent was evaporated under reduced pressure, washed with n-pentane and dried under reduced pressure to afford 0.2 g (47%) of 3-(pyridin-3-yl)butanamide as pale brown solid.

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. washwashed with n-pentane
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-fca5c3c5070245c3a401fb50552faf49
Source dataset
uspto-grants-2013_08
Patent number
US08518948B2

Reaction notes

Loading…