4'-Fluoroacetophenone → 4-(4-Methyl-1-piperazinyl)acetophenone

HRID 1896278Notes

Reaction equation

HRID 1896278 reaction equation
[CH3:1][C:2]([C:4]1[CH:9]=[CH:8][C:7](F)=[CH:6][CH:5]=1)=[O:3].[CH3:11][N:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1>>[CH3:11][N:12]1[CH2:17][CH2:16][N:15]([C:7]2[CH:8]=[CH:9][C:4]([C:2](=[O:3])[CH3:1])=[CH:5][CH:6]=2)[CH2:14][CH2:13]1

Participants

3

Reactant 2

HCID 98284'-FluoroacetophenoneHCID 531671-Methylpiperazine

Product 1

HCID 335514-(4-Methyl-1-piperazinyl)acetophenoneYield 94.5%

Procedure

A solution of 4-fluoro acetophenone (5.0 g, 3.6 mmol) and N-methyl piperazine (20 ml, 4 vol %) was heated in a sealed tube at 120° C. for 16 h. The reaction mixture was cooled to room temperature and poured into ice water. The precipitated solid was filtered and dried in vacuo to afford 7.50 g (94.5%) of 1-(4-(4-methylpiperazin-1-yl)phenyl)ethanone as solid.

Workup

  1. filtrationThe precipitated solid was filtered
  2. customdried in vacuo

Sources & evidence

ORD record
ord-66b6bbd8b9234c36b8f7d46297bdc726
Source dataset
uspto-grants-2013_08
Patent number
US08518948B2

Reaction notes

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