Nitromethane → HCID 57743020, compound

HRID 1896360Notes

Reaction equation

HRID 1896360 reaction equation
[F:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([F:9])=[CH:4][C:3]=1[CH:10]=[CH:11][C:12]([O:14]CC)=O.[N+:17]([CH3:20])([O-])=O>>[F:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([F:9])=[CH:4][C:3]=1[CH:10]1[CH2:20][NH:17][C:12](=[O:14])[CH2:11]1

Participants

3

Reactant 2

HCID 6375NitromethaneHCID 86631463HCID 86631463, compound

Product 1

HCID 57743020HCID 57743020, compound

Procedure

4-(2,3,5-trifluorophenyl)pyrrolidin-2-one x38 is synthesized from nitromethane and ethyl 3-(2,3,5-trifluorophenyl)acrylate according to the methodology described in Kenda B. et al., J. Med. Chem. (2004), 47, 530-549.

Sources & evidence

ORD record
ord-97733bd11b584f4d97e07abc16b6f16a
Source dataset
uspto-grants-2013_08
Patent number
US08518943B2

Reaction notes

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