Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Malonic Acid | HCID 867 | — |
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 5-Chloro-1-benzothiophene-2-carbaldehyde | HCID 18467050 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 59198425 | HCID 59198425 | — |
Reaction Steps
A mixture containing 5-chlorobenzo[b]thiophene-2-carboxaldehyde (Matsunaga Bioorg. Med. Chem. 2004, 12, 2251), malonic acid (1.4 equiv), pyridine (2.5 equiv) and piperidine (0.1 equiv) was heated at 110° C. for a period of 4 h. The reaction mixture was cooled, poured into H2O and filtered to provide the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08518964B2 |
|---|
| Source dataset | uspto-grants-2013_08 |
|---|
| ORD ID | ord-952c4aea9fc64188bf129954996c697f |
|---|
| Source note | uspto-grants-2013_08 |
|---|
