Water → HCID 178517586, compound

HRID 1896496Notes

Reaction equation

HRID 1896496 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[S:14][C:13]3[CH:12]=[CH:11][N:10]=[C:9]([OH:15])[C:8]=3[C:6]=2[CH:7]=1.[Br:16]Br.O>CC(O)=O>[Br:16][C:12]1[C:13]2[S:14][C:5]3[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][C:6]=3[C:8]=2[C:9]([OH:15])=[N:10][CH:11]=1

Participants

5

Reactant 3

HCID 962WaterHCID 24408BromineHCID 178517700HCID 178517700, compound

Product 1

HCID 178517586HCID 178517586, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
120 °C

Procedure

To 8-chloro[1]benzothieno[3,2-c]pyridine-1-ol in AcOH (0.3 M) was added Br2 (1.1 equiv). The resulting mixture was heated at 120° C. for 1 h, cooled to room temperature, poured into H2O and filtered. The solid was suspended in acetone, sonicated and filtered to provide the title compound.

Workup

  1. temperaturecooled to room temperature
  2. filtrationfiltered
  3. customsonicated
  4. filtrationfiltered

Sources & evidence

ORD record
ord-4a93b028c2bc4826bd0bcae9da0c9af9
Source dataset
uspto-grants-2013_08
Patent number
US08518964B2

Reaction notes

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