HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → HCID 59198428, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | HCID 178510358 | HCID 178510358 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 59198428 | HCID 59198428 | — |
Reaction Conditions
| Temperature | 175 °C |
|---|
Reaction Steps
A mixture of 1-hydroxy-7-(trifluoromethyl)-5H-pyrido[4,3-b]indole-4-carbonitrile in an excess of POCl3 was heated in a microwave apparatus at 175° C. for a period of 13 min. The reaction mixture was poured slowly into cold EtOAc and saturated NaHCO3. The organic phase was separated, dried over Na2SO4, filtered and evaporated to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08518964B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-2ccfc253954144e38c40b7b88ce85f1b |
| Source note | uspto-grants-2013_08 |