Water → 1-Amino-7-bromo[1]benzothieno[3,2-c]pyridine-4-carboxamide

HRID 1896527Notes

Reaction equation

HRID 1896527 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]2[C:8]3[C:9]([NH:17]CC4C=CC(OC)=CC=4)=[N:10][CH:11]=[C:12]([C:15]#[N:16])[C:13]=3[S:14][C:4]=2[CH:3]=1.O.[O-:28]P([O-])([O-])=O.[K+].[K+].[K+]>OS(O)(=O)=O>[NH2:17][C:9]1[C:8]2[C:5]3[CH:6]=[CH:7][C:2]([Br:1])=[CH:3][C:4]=3[S:14][C:13]=2[C:12]([C:15]([NH2:16])=[O:28])=[CH:11][N:10]=1

Participants

5

Reactant 3

HCID 962WaterHCID 62657Potassium Phosphate, TribasicHCID 591984657-Bromo-1-[(4-methoxybenzyl)amino][1]benzothieno[3,2-c]pyridine-4-carbonitrile

Product 1

HCID 235819291-Amino-7-bromo[1]benzothieno[3,2-c]pyridine-4-carboxamide

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

A solution of 7-bromo-1-[(4-methoxybenzyl)amino][1]benzothieno[3,2-c]pyridine-4-carbonitrile in conc. H2SO4 (0.04 M) was stirred at room temperature for 2 h. The mixture was poured into H2O, neutralized with K3PO4, filtered, washed with H2O and dried. The crude product was swished with MeOH to give the title compound.

Workup

  1. filtrationfiltered
  2. washwashed with H2O
  3. customdried

Sources & evidence

ORD record
ord-02a9646cb8124e57b6fa12c8db2d2fa2
Source dataset
uspto-grants-2013_08
Patent number
US08518964B2

Reaction notes

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