Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diethylamine | HCID 8021 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 4-(Methanesulfonyl)phenylboronic acid | HCID 2734364 | — |
| Reactant | 7-Bromo-1-[(4-methoxybenzyl)amino][1]benzothieno[3,2-c]pyridine-4-carbonitrile | HCID 59198465 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Product | HCID 59198486 | HCID 59198486 | — |
Reaction Steps
To a suspension of 7-bromo-1-[(4-methoxybenzyl)amino][1]benzothieno[3,2-c]pyridine-4-carbonitrile (Example 12, Step 9) and [4-(methylsulfonyl)phenyl]boronic acid (1.5 equiv) in 1-PrOH/H2O (4.5/1) (0.11 M) was added Pd2(dba)3 (0.03 equiv), Ph3P (0.06 equiv) and Et2NH (1.2 equiv). The mixture was degassed and heated to 150° C. for 10 min in a microwave reactor. The mixture was diluted with H2O and filtered. The crude product was swished with hot EtOH to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08518964B2 |
|---|
| Source dataset | uspto-grants-2013_08 |
|---|
| ORD ID | ord-3aa2590f909f4a43b8a4a97c867c20a8 |
|---|
| Source note | uspto-grants-2013_08 |
|---|
