Water → HCID 23582060, compound

HRID 1896548Notes

Reaction equation

HRID 1896548 reaction equation
COC1C=CC(C[NH:8][C:9]2[C:14]3[C:15]4[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][C:16]=4[S:17][C:13]=3[C:12]([C:26]#[N:27])=[CH:11][N:10]=2)=CC=1.O.[OH-].[K+].[O-:33]P([O-])([O-])=O.[K+].[K+].[K+]>OS(O)(=O)=O>[NH2:8][C:9]1[C:14]2[C:15]3[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][C:16]=3[S:17][C:13]=2[C:12]([C:26]([NH2:27])=[O:33])=[CH:11][N:10]=1

Participants

6

Reactant 4

HCID 962WaterHCID 14797Potassium HydroxideHCID 62657Potassium Phosphate, TribasicHCID 59198485HCID 59198485, compound

Product 1

HCID 23582060HCID 23582060, compound

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

A solution of 1-[(4-methoxybenzyl)amino]-7-(trifluoromethyl)[1]benzothieno[3,2-c]pyridine-4-carbonitrile in conc. H2SO4 (0.1 M) was stirred at room temperature for 2 h. The mixture was poured into H2O, neutralized with KOH and K3PO4 solution to pH 9. The solid was filtered then swished with boiling H2O to give the title compound.

Workup

  1. filtrationThe solid was filtered

Sources & evidence

ORD record
ord-2b63c688782d4e6f9155cc40604fb42b
Source dataset
uspto-grants-2013_08
Patent number
US08518964B2

Reaction notes

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