Potassium Carbonate → HCID 59418698, compound

HRID 1896619Notes

Reaction equation

HRID 1896619 reaction equation
[CH3:1][O:2][C:3]1[CH:10]=[CH:9][C:6]([CH2:7]Br)=[CH:5][CH:4]=1.[Br:11][C:12]1[N:17]=[C:16]([C:18]([O:20][CH3:21])=[O:19])[C:15]([OH:22])=[CH:14][CH:13]=1.C([O-])([O-])=O.[K+].[K+]>CC(C)=O>[Br:11][C:12]1[N:17]=[C:16]([C:18]([O:20][CH3:21])=[O:19])[C:15]([O:22][CH2:7][C:6]2[CH:9]=[CH:10][C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)=[CH:14][CH:13]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 1650214-Methoxybenzyl bromideHCID 22175135Methyl 6-bromo-3-hydroxypicolinate

Product 1

HCID 59418698HCID 59418698, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

4-Methoxybenzyl bromide (0.095 g, 0.47 mmol) was added dropwise to a suspension of methyl 6-bromo-3-hydroxypicolinate (26B) (0.100 g, 0.43 mmol) and K2CO3 (0.089 g, 0.65 mmol) in anhydrous acetone (2.5 mL). The reaction mixture was heated at reflux for 3.5 hours, cooled to rt, and concentrated under reduced pressure. Water was added and the mixture extracted with DCM. The organic phases were washed with 1 M NaOH, brine, dried over MgSO4, filtered, and concentrated under reduced pressure. The concentrate was purified by column chromatography on silica gel eluting with a gradient of PE:EtOAc 84:16 to 72:28, to provide the desired product methyl 6-bromo-3-(4-methoxybenzyloxy)picolinate (40A).

Workup

  1. temperatureThe reaction mixture was heated
  2. temperatureat reflux for 3.5 hours
  3. concentrationconcentrated under reduced pressure
  4. additionWater was added
  5. extractionthe mixture extracted with DCM
  6. washThe organic phases were washed with 1 M NaOH, brine
  7. dry with materialdried over MgSO4
  8. filtrationfiltered
  9. concentrationconcentrated under reduced pressure
  10. customThe concentrate was purified by column chromatography on silica gel eluting with a gradient of PE

Sources & evidence

ORD record
ord-8ee0481e026e46a281787e8bac20582d
Source dataset
uspto-grants-2013_08
Patent number
US08518970B2

Reaction notes

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