反应详情

Under argon, 400 mg (1.46 mmol) of 3-(6-(2-fluorophenyl)pyridin-3-yl)propionic acid ethyl ester and 63.8 mg (2.93 mmol) of lithium borohydride were stirred in 20 ml of THF at 40° C. for 3 h. After cooling, the mixture was cautiously hydrolyzed with water, the precipitate was filtered off with suction, and water and methylene chloride were added to the filtrate. The organic phase was separated, washed with water and concentrated. Yield: 241 mg (71%).

1. temperatureAfter cooling
2. filtrationthe precipitate was filtered off with suction, and water and methylene chloride
3. additionwere added to the filtrate
4. customThe organic phase was separated
5. washwashed with water
6. concentrationconcentrated