2-Piperidone → 1-(3-(6-(2-Fluorophenyl)pyridin-3-yl)propyl)piperidin-2-one

HRID 1896695Notes

Reaction equation

HRID 1896695 reaction equation
Br[CH2:2][CH2:3][CH2:4][C:5]1[CH:6]=[CH:7][C:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[F:17])=[N:9][CH:10]=1.[NH:18]1[CH2:23][CH2:22][CH2:21][CH2:20][C:19]1=[O:24]>>[F:17][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=1[C:8]1[N:9]=[CH:10][C:5]([CH2:4][CH2:3][CH2:2][N:18]2[CH2:23][CH2:22][CH2:21][CH2:20][C:19]2=[O:24])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 126652-PiperidoneHCID 691059795-(3-Bromopropyl)-2-(2-fluorophenyl)pyridine

Product 1

HCID 160366521-(3-(6-(2-Fluorophenyl)pyridin-3-yl)propyl)piperidin-2-one

Procedure

50 mg (0.17 mmol) of 5-(3-bromopropyl)-2-(2-fluorophenyl)pyridine were reacted with 18.5 mg (0.18 mmol) of piperidin-2-one analogously to example 1d). Yield: 16 mg (31%).

Sources & evidence

ORD record
ord-df95b7949afa463d87910924e2cebe44
Source dataset
uspto-grants-2013_08
Patent number
US08518976B2

Reaction notes

Loading…