反应详情

300 mg (1.38 mmol) of 3-(6-bromopyridin-3-yl)propan-1-ol were stirred in 5 ml of hydrobromic acid (33% in acetic acid) at 80° C. for 6 h. After concentrating, a potassium carbonate solution was added, the resulting mixture was extracted with ethyl acetate, and the organic phase was separated and concentrated. Yield: 368 mg (95%).

1. concentrationAfter concentrating
2. additiona potassium carbonate solution was added
3. extractionthe resulting mixture was extracted with ethyl acetate
4. customthe organic phase was separated
5. concentrationconcentrated