反应详情

Under argon, 675 mg (2.58 mmol) of (6-(2-fluorophenyl)pyridin-3-yloxy)acetic acid methyl ester and 112.5 mg (5.17 mmol) of lithium borohydride were stirred in 20 ml of THF at 60° C. for 2 h. After cooling, the mixture was cautiously hydrolyzed with water and concentrated, and water and ethyl acetate were added. The organic phase was separated, washed with water and concentrated. Yield: 350 mg (58%).

1. temperatureAfter cooling
2. concentrationconcentrated
3. additionwater and ethyl acetate were added
4. customThe organic phase was separated
5. washwashed with water
6. concentrationconcentrated