Water → 2-(4-Fluorophenyl)-2-oxoethyl thiocyanate

HRID 1896709Notes

Reaction equation

HRID 1896709 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][CH:6]=1)=[O:4].[S-:12][C:13]#[N:14].[Na+].O>C(O)C>[F:11][C:8]1[CH:9]=[CH:10][C:5]([C:3](=[O:4])[CH2:2][S:12][C:13]#[N:14])=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 962WaterHCID 967492-Bromo-1-(4-fluorophenyl)ethan-1-oneHCID 516871Sodium thiocyanate

Product 1

HCID 41989922-(4-Fluorophenyl)-2-oxoethyl thiocyanate

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

10 g (46 mmol) of 2-bromo-1-(4-fluorophenyl)ethanone and 3.74 g (46 mmol) of sodium thiocyanate were stirred in 80 ml ethanol at 50° C. for 2 h. After addition of water the separated solid was isolated by filtration, washed and dried. Yield: 8.96 g.

Workup

  1. customwas isolated by filtration
  2. washwashed
  3. customdried

Sources & evidence

ORD record
ord-cac41fc3dcc144c4a528f96636b9ede9
Source dataset
uspto-grants-2013_08
Patent number
US08518976B2

Reaction notes

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