HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → 2-(6-(2-Fluorophenyl)pyridin-3-yloxy)ethylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 2-(2-(6-(2-Fluorophenyl)pyridin-3-yloxy)ethyl)isoindole-1,3-dione | HCID 59761352 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-(6-(2-Fluorophenyl)pyridin-3-yloxy)ethylamine | HCID 69105919 | — |
Reaction Steps
189 mg (0.52 mmol) of (2-(2-(6-(2-fluorophenyl)pyridin-3-yloxy)ethyl)isoindole-1,3-dione and 236 mg (4.72 mmol) of hydrazine hydrate (24%) were stirred in 10 ml of ethanol under reflux for 7 h. After cooling the residue was filtered, washed and dried. Yield: 165 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08518976B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-b507f9d03dcb418792a315e246576b0c |
| Source note | uspto-grants-2013_08 |