Hydrazine hydrate (1:1) → 2-(6-(2-Fluorophenyl)pyridin-3-yloxy)ethylamine

HRID 1896710Notes

Reaction equation

HRID 1896710 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:13]=[CH:12][C:11]([O:14][CH2:15][CH2:16][N:17]2C(=O)C3C(=CC=CC=3)C2=O)=[CH:10][CH:9]=1.O.NN>C(O)C>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:13]=[CH:12][C:11]([O:14][CH2:15][CH2:16][NH2:17])=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 597613522-(2-(6-(2-Fluorophenyl)pyridin-3-yloxy)ethyl)isoindole-1,3-dione

Product 1

HCID 691059192-(6-(2-Fluorophenyl)pyridin-3-yloxy)ethylamine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

189 mg (0.52 mmol) of (2-(2-(6-(2-fluorophenyl)pyridin-3-yloxy)ethyl)isoindole-1,3-dione and 236 mg (4.72 mmol) of hydrazine hydrate (24%) were stirred in 10 ml of ethanol under reflux for 7 h. After cooling the residue was filtered, washed and dried. Yield: 165 mg.

Workup

  1. temperatureunder reflux for 7 h
  2. temperatureAfter cooling the residue
  3. filtrationwas filtered
  4. washwashed
  5. customdried

Sources & evidence

ORD record
ord-b507f9d03dcb418792a315e246576b0c
Source dataset
uspto-grants-2013_08
Patent number
US08518976B2

Reaction notes

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