反应详情

温度

100 °C

A mixture of 2-chloro-5-nitrobenzo[d]oxazole (404 mg, 2.04 mmol), 2-(tributylstannyl)-thiophene (648 μL, 2.04 mmol) and tetrakis(triphenylphosphine)palladium (0) (40.8 mg) in dioxane (12.2 mL) was heated at 100° C. for 16 h under nitrogen. Ethyl acetate was added, the organic layer was washed with water, dried over anhydrous MgSO4 and evaporated. The resulting solid was purified by column chromatography eluting with ethyl acetate/hexanes 10:90 v/v, and then purified by reverse phase HPLC to afford 3 mg (2%) of the title product (LCMS RT=6.95 min)

1. washthe organic layer was washed with water
2. dry with materialdried over anhydrous MgSO4
3. customevaporated
4. customThe resulting solid was purified by column chromatography
5. washeluting with ethyl acetate/hexanes 10:90 v/v
6. custompurified by reverse phase HPLC