2-Chlorobenzoic Acid → 2-(2-Chlorophenyl)-5-nitrobenzo[d]thiazole

HRID 1896773노트

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HRID 1896773 반응식
[NH2:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:4][C:3]=1[SH:11].[Cl:12][C:13]1[CH:21]=[CH:20][CH:19]=[CH:18][C:14]=1[C:15](O)=O.CS(O)(=O)=O.O=P12OP3(OP(OP(O3)(O1)=O)(=O)O2)=O.[OH-].[Na+]>O>[Cl:12][C:13]1[CH:21]=[CH:20][CH:19]=[CH:18][C:14]=1[C:15]1[S:11][C:3]2[CH:4]=[CH:5][C:6]([N+:8]([O-:10])=[O:9])=[CH:7][C:2]=2[N:1]=1

참가 물질

6

반응물 4

HCID 83742-Chlorobenzoic AcidHCID 14798Sodium HydroxideHCID 63364002-Amino-4-nitrobenzenethiolHCID 86584057Phosphorus Pentoxide-Methanesulfonic Acid

생성물 1

HCID 673335012-(2-Chlorophenyl)-5-nitrobenzo[d]thiazole수율 98.5%

시약·촉매·용매 1

HCID 962Water용매

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온도
130 °C

실험 절차

2-Amino-4-nitrobenzenethiol (315 mg, 1.85 mmol), 2-chlorobenzoic acid (290 mg, 1.85 mmol) and Eaton's reagent (5 mL) were combined and heated in the microwave at 130° C. for 10 min. After cooling, the mixture was poured into water and basified with 5M aqueous sodium hydroxide to give a precipitate, which was filtered off and dried to afford 530 mg (98%) of the title compound.

후처리

  1. temperatureAfter cooling
  2. customto give a precipitate, which
  3. filtrationwas filtered off
  4. customdried

출처 및 근거

ORD 기록
ord-0d0483f5ac964d46851891e7aeae97b7
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08518980B2

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