反应详情

温度

70 °C

1-methyl-6-nitro-1H-indole (90 mg, 0.51 mmol), ammonium chloride (55 mg, 1.02 mmol) and iron powder (143 mg, 2.55 mmol) were suspended in ethanol/water (2 mL/1 mL) and heated at 70° C. for 2 h. After cooling, the solution was filtrated through a pad of Celite®, which was washed with ethanol. Ethyl acetate was added to the filtrate and the organic layer was washed with water twice. The combined organic layers were dried over anhydrous MgSO4 and evaporated to afford 30 mg (37%) of the title compound

1. temperatureAfter cooling
2. filtrationthe solution was filtrated through a pad of Celite®, which
3. washwas washed with ethanol
4. additionEthyl acetate was added to the filtrate
5. washthe organic layer was washed with water twice
6. dry with materialThe combined organic layers were dried over anhydrous MgSO4
7. customevaporated