反应详情

A solution of 2-(1,4-dioxa-spiro[4.5]dec-7-en-8-yl)-pyridin-3-ol (1.3 g, 5.573 mmol) in methanol (60 mL) added to palladium (II) hydroxide (330 mg, 0.62 mmol) in a Parr bottle under argon. The reaction mixture was degassed with argon, evacuated and backfilled with hydrogen then shaken under 50 psi the gas at ambient temperature for 24 hours. After depressurizing and bubbling with argon, the reaction mixture was filtered through Celite 521, washing the filter with MeOH, and filtrate evaporated in vacuo giving a white solid.

1. customThe reaction mixture was degassed with argon
2. customevacuated
3. custombubbling with argon
4. filtrationthe reaction mixture was filtered through Celite 521
5. washwashing the
6. filtrationfilter with MeOH, and filtrate
7. customevaporated in vacuo
8. customgiving a white solid