反应详情

温度

50 °C

A solution of N-(1-(4,4-dimethoxycyclohexyl)but-3-en-1-yl)acrylamide (512 mg, 2.4 mmol), prepared in the previous step, and the Grubbs Generation II catalyst (97 mg, 0.11 mmol) in DCE (100 mL) was degassed and heated to 50° C. under argon for 2 hours. The reaction mixture was concentrated in vacuo and the residue purified by flash chromatography (silica gel, DCM→0-5% MeOH/ethyl acetate) to afford the product.

1. concentrationThe reaction mixture was concentrated in vacuo
2. customthe residue purified by flash chromatography (silica gel, DCM→0-5% MeOH/ethyl acetate)
3. customto afford the product