反应详情

温度

50 °C

A solution of N-(1-(1,4-dioxaspiro[4.5]decan-8-yl)allyl)acrylamide (560 mg, 2.23 mmol), prepared in the previous step, and the Grubbs Generation II catalyst (95 mg, 0.11 mmol) in DCE (50 mL) was degassed and heated to 50° C. under argon for 2 hours. The reaction mixture was concentrated in vacuo and the residue purified by flash chromatography (silica gel, DCM→0-5% MeOH/ethyl acetate) to afford the product.

1. concentrationThe reaction mixture was concentrated in vacuo
2. customthe residue purified by flash chromatography (silica gel, DCM→0-5% MeOH/ethyl acetate)
3. customto afford the product