HCID 58562553, compound → HCID 58562755, compound

HRID 1896822Notes

Reaction equation

HRID 1896822 reaction equation
[O:1]1[CH2:6][CH:5]=[CH:4][CH2:3][CH:2]1[CH:7]1[CH2:16][CH2:15][C:10]2([O:14][CH2:13][CH2:12][O:11]2)[CH2:9][CH2:8]1>[Pd].CO>[O:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[CH:7]1[CH2:16][CH2:15][C:10]2([O:11][CH2:12][CH2:13][O:14]2)[CH2:9][CH2:8]1

Participants

4

Reactant 1

HCID 58562553HCID 58562553, compound

Product 1

HCID 58562755HCID 58562755, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a mixture of 8-(3,6-dihydro-2H-pyran-2-yl)-1,4-dioxaspiro[4.5]decane (190 mg, 0.847 mmol), as prepared in Example 2 step C, and Palladium on Carbon (118 mg, 0.055 mmol, 5%, “Degussa, wet”) was carefully added methanol (24 mL). The reaction flask was evacuated, backfilled with hydrogen via balloon and stirred at room temperature overnight. The catalyst was removed by filtration and the filtrate concentrated in vacuo to afford the product.

Workup

  1. customThe reaction flask was evacuated
  2. customThe catalyst was removed by filtration
  3. concentrationthe filtrate concentrated in vacuo
  4. customto afford the product

Sources & evidence

ORD record
ord-9fca4bc88dcc4219a9c34ceb7440cad8
Source dataset
uspto-grants-2013_08
Patent number
US08518969B2

Reaction notes

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