反应详情

温度

0 °C

To a solution of 8-vinyl-1,4-dioxaspiro[4.5]decane (370 mg, 2.20 mmol), prepared as described in Example 9 Step A, in DCM (20 mL) cooled to 0° C. was added mCPBA (532 mg, 2.37 mmol, 77%). The mixture was stirred warming to room temperature over 1 hour and then concentrated in vacuo without heating. The residue was purified by flash chromatography (silica gel, 0-50% ether/DCM) to afford the product.

1. temperaturewarming to room temperature over 1 hour
2. concentrationconcentrated in vacuo
3. temperaturewithout heating
4. customThe residue was purified by flash chromatography (silica gel, 0-50% ether/DCM)
5. customto afford the product