Tetrabutylammonium Fluoride → 8-Hydroxy-8-(5-thiazolyl)-1,4-dioxaspiro[4.5]decane

HRID 1896838Notes

Reaction equation

HRID 1896838 reaction equation
C[Si](C)(C)[C:3]1[S:4][C:5]([C:8]2([OH:18])[CH2:17][CH2:16][C:11]3([O:15][CH2:14][CH2:13][O:12]3)[CH2:10][CH2:9]2)=[CH:6][N:7]=1.CCCC[N+](CCCC)(CCCC)CCCC.[F-]>>[S:4]1[C:5]([C:8]2([OH:18])[CH2:9][CH2:10][C:11]3([O:15][CH2:14][CH2:13][O:12]3)[CH2:16][CH2:17]2)=[CH:6][N:7]=[CH:3]1

Participants

3

Reactant 2

HCID 2724141Tetrabutylammonium FluorideHCID 57803270HCID 57803270, compound

Product 1

HCID 590174418-Hydroxy-8-(5-thiazolyl)-1,4-dioxaspiro[4.5]decane

Procedure

The title compound was prepared as white solid from 8-(2-trimethylsilanyl-thiazol-5-yl)-1,4-dioxa-spiro[4.5]decan-8-ol followed by TBAF work-up.

Sources & evidence

ORD record
ord-ff8a9ec72e5545f38fdb241c3d0ffbb4
Source dataset
uspto-grants-2013_08
Patent number
US08518969B2

Reaction notes

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