反应详情

1,4-dioxaspiro[4.5]decan-8-one (2 g, 12.8 mmol), and ethylamine (6.4 mL, 12.8 mmol), and sodium triacetoxyborohydride (8 g, 38 mmol) were taken in acetonitrile and stirred for 18 h at room temperature. The mixture concentrated under vacuum and the residue basified with NaHCO3, saturated with solid NaCl and extracted with EtOAc/iPrOH (4:1) four times. Organic layer separated, dried over Na2SO4 and evaporated to give the title compound.

1. concentrationThe mixture concentrated under vacuum
2. extractionextracted with EtOAc/iPrOH (4:1) four times
3. customOrganic layer separated
4. dry with materialdried over Na2SO4
5. customevaporated