反应详情

Benzyl propyl(1,4-dioxaspiro[4.5]decan-8-yl)carbamate (350 mg, 1.1 mmol) was dissolved in acetonitrile, treated with 6N HCl, and stirred at room temperature for 18 h. reaction mixture was concentrated in vacuo, treated with saturated NaHCO3 to pH 6. The solvents were removed under vacuum and the residue treated with saturated NaCl (2 mL) and extracted with 4:1 EtOAc/iPrOH (×4). The organic fractions were combined, filtered and evaporated to give the title compound.

1. customreaction mixture
2. concentrationwas concentrated in vacuo
3. additiontreated with saturated NaHCO3 to pH 6
4. customThe solvents were removed under vacuum
5. additionthe residue treated with saturated NaCl (2 mL)
6. extractionextracted with 4:1 EtOAc/iPrOH (×4)
7. filtrationfiltered
8. customevaporated