反应详情

1-(1,4-dioxaspiro[4.5]decan-8-yl)pyrrolidine-2,5-dione (60 mg, 0.25 mmol) from above step A, was dissolved in acetonitrile, treated with 6N HCl, and stirred at room temperature for 18 h. The reaction mixture was concentrated in vacuo, treated with saturated NaHCO3 to pH 6. The solvents were removed under vacuum and the residue treated with saturated NaCl (2 mL) and extracted with 4:1 EtOAc/iPrOH (×4). The organic fractions were combined, filtered and evaporated to give the title compound.

1. concentrationThe reaction mixture was concentrated in vacuo
2. additiontreated with saturated NaHCO3 to pH 6
3. customThe solvents were removed under vacuum
4. additionthe residue treated with saturated NaCl (2 mL)
5. extractionextracted with 4:1 EtOAc/iPrOH (×4)
6. filtrationfiltered
7. customevaporated