反应详情

A solution of 4-((4-methoxybenzyl)oxy)-6-(trifluoromethyl)quinoline-2-carbonitrile (5 g, 14 mmol) from above step C, in 15 mL DCM and 45 mL TFA was stirred for 2 h. Solvent was removed under vacuum and the residue was evaporated form toluene twice. The residue was dried under high vacuum. The resulting yellow solid was triturated with hot toluene, filtered and washed with ether to provide the title compound as a white solid.

1. customSolvent was removed under vacuum
2. customthe residue was evaporated form toluene twice
3. customThe residue was dried under high vacuum
4. customThe resulting yellow solid was triturated with hot toluene
5. filtrationfiltered
6. washwashed with ether