2-Iodophenol → HCID 54772205, Verbindung

HRID 1896898Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1896898
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]1.IC1C=CC=CC=1O.CC1(C)C(C)(C)OB(C2CCC3(OCCO3)CC=2)O1.[NH:42]1[CH2:45][CH:44]([NH:46][C:47](=[O:64])[CH2:48][NH:49][C:50]2[C:59]3[C:54](=[CH:55][CH:56]=[C:57]([C:60]([F:63])([F:62])[F:61])[CH:58]=3)[N:53]=[CH:52][N:51]=2)[CH2:43]1.[BH-](OC(C)=O)(OC(C)=O)OC(C)=O.[Na+]>>[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[CH2:13][CH2:12][CH:11]([N:42]2[CH2:43][CH:44]([NH:46][C:47](=[O:64])[CH2:48][NH:49][C:50]3[C:59]4[C:54](=[CH:55][CH:56]=[C:57]([C:60]([F:61])([F:63])[F:62])[CH:58]=4)[N:53]=[CH:52][N:51]=3)[CH2:45]2)[CH2:10][CH2:9]1

Komponenten

6

Edukt 5

HCID 107842-IodophenolHCID 36970768-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4-dioxaspiro(4.5)dec-7-eneHCID 5049666Sodium triacetoxyborohydrideHCID 18352378HCID 18352378, VerbindungHCID 68003594N-(azetidin-3-yl)-2((6-(trifluoromethyl)quinazolin-4-yl)amino)acetamide

Produkt 1

HCID 54772205HCID 54772205, Verbindung

Versuchsvorschrift

Reaction of 4-(2-hydroxyphenyl)cyclohexanone (prepared by the reaction of 2-iodophenol with 8-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-1,4-dioxa-spiro[4.5]dec-7-ene using the sequence described in Example 1 Step A-C) with N-(azetidin-3-yl)-2-((6-(trifluoromethyl)quinazolin-4-yl)amino)acetamide (as prepared in Example 1 Step G) in the presence of TEA and NaBH(OAc)3 as described in Example 1, Step H afforded the product.

Aufarbeitung

  1. customafforded the product

Quellen und Nachweise

ORD-Eintrag
ord-9eee7c957c65447b984c697991616a43
Quelldatensatz
uspto-grants-2013_08
Patentnummer
US08518969B2

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