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HRID1896910

反应详情

EQUATION

反应方程式

HRID 1896910 的结构方程式

REACTANTS

反应物

3
结构：O=C1CCC2(CC1)OCCO2
HCID567415

1,4-Dioxaspiro[4.5]decan-8-one

C8H12O3

结构：CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+]
HCID5049666

Sodium triacetoxyborohydride

C6H10BNaO6

结构：O=C(CNc1ncnc2ccc(C(F)(F)F)cc12)NC1CNC1
HCID68003594

未命名化合物

PRODUCTS

生成物

1
结构：O=C1CCC(N2CC(NC(=O)CNc3ncnc4ccc(C(F)(F)F)cc34)C2)CC1
HCID54770393

未命名化合物

PROCEDURE

实验过程

Reaction of 1,4-dioxaspiro[4.5]decan-8-one with N-(azetidin-3-yl)-2-((6-(trifluoromethyl)quinazolin-4-yl)amino)acetamide (as prepared in Example 1 Step G) in the presence of TEA and NaBH(OAc)3 as described in Example 1, Step H followed by acidic deprotection of the ketal afforded the product.

WORKUP

后处理

  1. customafforded the product