4-Methylcyclohexanone → HCID 68004063, compound

HRID 1896916Notes

Reaction equation

HRID 1896916 reaction equation
[CH3:1][CH:2]1[CH2:7][CH2:6][C:5](=O)[CH2:4][CH2:3]1.[NH:9]1[CH2:12][CH:11]([NH:13][C:14](=[O:31])[CH2:15][NH:16][C:17]2[C:26]3[C:21](=[CH:22][CH:23]=[C:24]([C:27]([F:30])([F:29])[F:28])[CH:25]=3)[N:20]=[CH:19][N:18]=2)[CH2:10]1.[BH-](OC(C)=O)(OC(C)=O)OC(C)=O.[Na+]>>[CH3:1][CH:2]1[CH2:7][CH2:6][CH:5]([N:9]2[CH2:10][CH:11]([NH:13][C:14](=[O:31])[CH2:15][NH:16][C:17]3[C:26]4[C:21](=[CH:22][CH:23]=[C:24]([C:27]([F:28])([F:30])[F:29])[CH:25]=4)[N:20]=[CH:19][N:18]=3)[CH2:12]2)[CH2:4][CH2:3]1

Participants

4

Reactant 3

HCID 115254-MethylcyclohexanoneHCID 5049666Sodium triacetoxyborohydrideHCID 68003594N-(azetidin-3-yl)-2((6-(trifluoromethyl)quinazolin-4-yl)amino)acetamide

Product 1

HCID 68004063HCID 68004063, compound

Procedure

Reaction of 4-methylcyclohexanone with N-(azetidin-3-yl)-2-((6-(trifluoromethyl)quinazolin-4-yl)amino)acetamide (as prepared in Example 1 Step G) in the presence of TEA and NaBH(OAc)3 as described in Example 1, Step H afforded the product.

Workup

  1. customafforded the product

Sources & evidence

ORD record
ord-af88d12659784b539890bbc1be6dd126
Source dataset
uspto-grants-2013_08
Patent number
US08518969B2

Reaction notes

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