反应详情

A solution of 1-(1-1,4-dioxaspiro[4.5]decan-8-ylpropyl)-3,3-dimethylurea (as prepared in the previous step, 36 mg, 0.13 mmol, 1.00 equiv) in CH3CN (5 mL) and HCl (2M, 1 mL) was stirred for 2 h at room temperature. The resulting mixture was concentrated under vacuum. The residue was diluted with 10 mL of aq. sodium bicarbonate (1M). The resulting solution was extracted with 2×20 mL of dichloromethane. The organic layers were combined, dried over anhydrous sodium sulfate and concentrated under vacuum. The title compound was obtained as a yellow oil.

1. concentrationThe resulting mixture was concentrated under vacuum
2. additionThe residue was diluted with 10 mL of aq. sodium bicarbonate (1M)
3. extractionThe resulting solution was extracted with 2×20 mL of dichloromethane
4. dry with materialdried over anhydrous sodium sulfate
5. concentrationconcentrated under vacuum