HCID 58562770, compound → HCID 58562832, compound

HRID 1896955Notes

Reaction equation

HRID 1896955 reaction equation
[Si]([C:8]1[S:9][C:10]([C:13]2([OH:31])[CH2:18][CH2:17][N:16]([CH:19]3[CH2:22][CH:21]([NH:23]C(=O)OC(C)(C)C)[CH2:20]3)[CH2:15][CH2:14]2)=[CH:11][N:12]=1)(C(C)(C)C)(C)C>ClCCl.C(O)(C(F)(F)F)=O>[NH2:23][CH:21]1[CH2:22][CH:19]([N:16]2[CH2:15][CH2:14][C:13]([C:10]3[S:9][CH:8]=[N:12][CH:11]=3)([OH:31])[CH2:18][CH2:17]2)[CH2:20]1

Participants

4

Reactant 1

HCID 58562770HCID 58562770, compound

Product 1

HCID 58562832HCID 58562832, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

Into a 100 mL round-bottom flask, was placed a solution of tert-butyl 3-(4-(2-(tert-butyldimethylsilyl)thiazol-5-yl)-4-hydroxypiperidin-1-yl)cyclobutylcarbamate (as prepared in the previous step) (950 mg, 2.03 mmol, 1.00 equiv) in dichloromethane (10 mL) and CF3COOH (2 mL). The reaction mixture was stirred for 3 h at room temperature. The resulting mixture was concentrated under vacuum. The title compound was obtained as a yellow oil.

Workup

  1. customInto a 100 mL round-bottom flask, was placed
  2. concentrationThe resulting mixture was concentrated under vacuum

Sources & evidence

ORD record
ord-e01b3b779f044f3cacdaec43356465b8
Source dataset
uspto-grants-2013_08
Patent number
US08518969B2

Reaction notes

Loading…