Hydrazine hydrate (1:1) → HCID 22174882, compound

HRID 1897004Notes

Reaction equation

HRID 1897004 reaction equation
CS[C:3]1[N:8]=[C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=2)[N:6]=[CH:5][N:4]=1.O.[NH2:16][NH2:17]>C(O)C>[N:10]1[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=1[C:7]1[N:6]=[CH:5][N:4]=[C:3]([NH:16][NH2:17])[N:8]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 22174876HCID 22174876, compound

Product 1

HCID 22174882HCID 22174882, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A stirred solution of the product of step 2 (0.763 g, 3.74 mmol) and hydrazine hydrate (0.22 mL, 3.9 mmol) in ethanol (8 mL) was heated at reflux for 30 minutes. The reaction was cooled in an ice bath and the precipitate was filtered off. Vacuum oven drying afforded crude product as light brown solid. This material was used without further purification in the next step.

Workup

  1. temperatureat reflux for 30 minutes
  2. temperatureThe reaction was cooled in an ice bath
  3. filtrationthe precipitate was filtered off
  4. customVacuum oven drying
  5. customafforded crude product as light brown solid
  6. customThis material was used without further purification in the next step

Sources & evidence

ORD record
ord-c4ecbb6ddbbf4494a2d073d5fccf490a
Source dataset
uspto-grants-2013_08
Patent number
US08518999B2

Reaction notes

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